Surrogate Antibodies That Specifically Bind and Neutralize CCL17 But Not CCL22
نویسندگان
چکیده
منابع مشابه
Engagement of Two Distinct Binding Domains on CCL17 Is Required for Signaling through CCR4 and Establishment of Localized Inflammatory Conditions in the Lung
CCL17 (TARC) function can be completely abolished by mAbs that block either one of two distinct sites required for CCR4 signaling. This chemokine is elevated in sera of asthma patients and is responsible for establishing inflammatory sites through CCR4-mediated recruitment of immune cells. CCL17 shares the GPCR CCR4, with CCL22 (MDC) but these two chemokines differentially affect the immune res...
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ژورنال
عنوان ژورنال: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
سال: 2013
ISSN: 2167-9436,2167-9436
DOI: 10.1089/mab.2012.0112